How Viagra Works?

Mechanism of action of Viagra - How Viagra Works?

When a man is aroused, nerve signals are sent from a brain to the penis. This nerve signals releases chemicals (cGMP), which in turn relaxes muscle in the penis. When these muscles relax, large amount of blood enters the penis, causing an erection. In a man with Erectile dysfunction, another chemical called Phosphodiesterase type 5 (PDE 5) breaks down the the chemical used to relax the muscles (cGMP) and thus does not allow the blood to flow to penis and in turn cannot maintain an erection.

So if any how the PDE 5 chemical is inhibited the level of chemical cGMP would be increased and thus muscle relaxation in penis would be normal and thus more blood will flow to penis and a man could maintain an erection for longer period. This is where Viagra or Sildenafil Citrate comes into the picture.

Viagra (Sildenafil) works by blocking PDE 5. When PDE 5 is blocked the level of cGMP chemical is increased which causes more blood flow to penis and thus allows man to maintain erection for longer period.

One thing has to be very clear that, Viagra does not work without sexual stimulation or excitement. The chemicals that causes an erection has to be released into the penis and they are released only when a man is sexually aroused. Viagra does not help in releasing this chemicals it only helps in maintaining this chemicals for longer period.

Viagra once taken orally its effects begins within 15 to 30 minutes and lasts at least for 4 hours.

Viagra (Sildenafil Citrate)

What is Viagra (Sildenafil)?

Viagra or Sildenafil Citrate is a drug used for men to treat erectile dysfunction or Impotence. It is developed and brought to the market by Pharmaceutical company called Pfizer. It is available since 1998 and is the prime treatment for erectile dysfunction or impotence. Its competitors are Cialis and Levitra.

Looking into the history of Viagra in 1986 Pfizer found that by inhibiting phosphodiesterase type 5 (PDE 5) there can be many benefits for people suffering from inadequate blood supplies to the heart or angina. In 1989, they found that Sildenafil citrate powerfully inhibited PDE 5. Thus sildenafil was found to be used for inhibiting PDE 5 and thus help coronary arteries to  dilate and ease angina symptoms and avoid platelets to avoid sticking to the surface of damaged arteries where they might even trigger heart attacks.

However with the use of Sildenafil in males some unusual finding were reported, many reported a marked increase in getting erections.

Thus after carrying our further studies and testing on men with erectile dysfunction, it was proved that a single dose of Sildenafil (Viagra) could prmote erections in men who previously had problems of getting erections.

Finally in March 1998, Viagra was introduced as the first oral medication for the treatment of erectily dysfunction or impotence.

In period 1999-2001, the sales of Viagra exceeded the milestone of $1 Billion.

Precautions for Swine Flu in Pregnancy

Young age people who are usually observed in groups and those who are not good at immunity are most vulnerable to swine flu virus. Yes, Pregnant women are most susceptible to swine flu infections as their immune system in naturally suppressed in pregnancy. The evidence that influenza can be more severe in pregnant women is available from observations during previous pandemics and from studies among pregnant women who had seasonal influenza.

Most pregnant women will have similar symptoms as most of the people have during swine flu. However, pregnant women have an increased risk of complications fron any type of flu, because of their suppressed immune system. Some possible complications are pneumonia, difficulty breathing and dehydration more likely to happen in second or third month. There is however small chance that such complications may lead to premature birth or miscarriage.

Some precautions for swine flu during pregnancy:

• Avoid unnecessary travel
• Minimize contacts with sick individuals.
• Avoid crowds where ever possible
• Follow general hygiene advice, read general precautions for swine flu.
• Always be in contact with doctor if you have any of the symptoms of swine flu or even if any of your family member has swine flu.
• One should go on antiviral drugs only if doctor prescribes.

Pregnant women with influenza or H1N1 should receive empiric antiviral treatment. The drug of choice for treatment of pregnant women is oseltamivir i.e. Tamiflu. Treatment should ideally not be delayed. It should be initiated as soon as possible after the onset of influenza symptoms. It would be of greatest benefit if it is started within 48 hours of onset. Also this does not mean each and every women during pregnancy should immediately start taking Tamiflu if found symptoms of virus. But they should immediately contact doctor consult with them and they will surely prescribe Tamiflu if you have any kind of influenza symptoms. Thus better is to reach to doctor before 24 hours of onset of symptoms and start treatment Tamiflu before 48 hours if prescribed by doctor.

Infants are thought to be at higher risk for severe illness from novel influenza A (H1N1) infection as well and very little is known about prevention of novel H1N1 flu infection in infants. Infants who are not breastfeeding are more vulnerable to infection than infants who are breastfeeding. Women who are not ill with influenza should be encouraged to initiate breastfeeding early and feed frequently. Avoid unnecessary supplementation, so infant can receive as much maternal antibodies as possible.

If possible only adults who are not sick should care of infants, including providing feedings. The risk of H1N1 transmission through breast milk is unknown, however the risk of virus crossing into breast milk is also probably rare.

Parents and caretakers should take some precautions to avoid spread of virus.

• Follow general hygiene advice and cough etiquette all the time.
• Keep infant away from persons who are ill
• Keep infant away from crowded areas as well
• Avoid or limit sharing of toys that have been in infant's mouths. If possible wash thoroughly with soap and water any items before the use for infant if they have to be in their mouths.

Read more on Tamiflu.

Buy Tamiflu Online at best price.

Reference:
NHS UK
CDC
Meds4all

Tamiflu Cost

Swine flu also known as H1N1 is caused by infection due to influenza virus. Since H1N1 is a virus usually found in pigs, it is named as swine flu.

Treatments used for swine flu is similar to the one used in influenza. However there has been no vaccine prepared to cure swine flu. Many have now come up with few vaccines however their effect is yet to see. Tamiflu is the antiviral drug used to control influenza as well as swine flu. In this few months of swine flu pandemic, Tamiflu has become the only source of help to cure swine flu.

Swine flu treatments can be of two types:

• Preventive Treatment
• Using vaccine and medicines

Preventive treatment works only before a person actually catches infection. This treatment includes certain amount of precautions that are required. If you are not aware about precautions please read swine flu precautions.

Using vaccine and medicines is the option that can help you if you are already infected with swine flu virus. Since vaccine has not yet been in market or they have just come in market obviously with limited stock only hope left if you are infected with such virus is Tamiflu. Tamiflu should be used within 48 hours of a day you caught an infection. It will work only if you have followed about mentioned schedule. It will be better to have some Tamiflu from first if you are in area where swine flu has been recorded. To read more on Tamiflu read swine flu medicine.

Swine flu in UK - Update:

Swine flu in UK have rised by a third, major rise have been in England, Scotland and North Ireland. Thre is also some decrease in Wales. With three more swine flu related deaths in England and two in Scotland, death toll in UK rises to 79, 67 claiming only in England, 9 in Scotland while 2 in North Ireland.


Swine flu Treatment in UK:
Tamiflu is available in market and you can also buy them online. There are many pharmacies that sell generic Tamiflu. It is better to buy Brand Tamiflu other than Generic Tamiflu. Brand Tamiflu is produced by Swiss based Roche Laboratories. Very few online pharmacy or online clinic sell this Brand Tamiflu. Below you will find Tamiflu cost and the best online clinic source in UK where you can buy tamiflu online. This online clinic provides best pricing for Brand Tamiflu.

Product	Strength	Pill	Price (Euro)	Online clinic
Tamiflu	75mg	10	€ 150.00	Meds4all
Tamiflu	75mg	20	€ 255.00	Meds4all
Tamiflu	75mg	30	€ 355.00	Meds4all
Tamiflu	75mg	40	€ 460.00	Meds4all
Tamiflu	75mg	50	€ 565.00	Meds4all

Erectile Dysfunction Treatment

There are variety of treatments available for erectile dysfunction in men. So once you are diagnosed with  erectile dysfunction on that very day you can start with the suitable treatment and soon you can achieve your normal sex life.

However before starting with oral medication or any other treatment it is always better to make surety from your side. Your life style could be one of the cause among  various erectile dysfunction causes. So certain modification to your lifestyle can help you improve in getting your erection and enjoy your sexual life. ED is one of the sign of unhealthy lifestyle.

Here you will find some modification that you can bring in your lifestyle and improve the ability to get and sustain an erection for longer period.

If you are a hard core smoker, it can harden you arteries including those that supply the blood to your penis. Of course it is difficult to quit smoking, but you can try out certain support services catering to smoking cessation. You can even consult you GP for the same.

Exercise is must. Try to increase the amount of exercise if you are already putting some efforts. Exercise will improve your blood flow, relive you from stress, improves stamina, fitness, lifts your mood and will benefit your sexual life as well as your overall health.

Control on food intake. Controlling the food you eat is very important. Your body parts will function correctly if you supply them correct food. Try to avoid fatty food and caffeine, consume less sugar and salt and eat more fruits and vegetables. Very important, moderate the consumption of alcohol. Alcohol can worsen ED. Try to stick to the moderate or safe limit of not more than 3 units of alcohol per day. Don't drink everyday and don't get drunk before sex.

Improve your daily lifestyle or balance between your work life and personal life. Overwork or work pressure leads to tension and stress and you will always find yourself exhausted. Try to avoid as much as possible all the things that can cause a tension in your relationship. Try to take more sleep and leave fresh life that will not only improve you health but your confidence as well. Take some time out from your work to get relax and spend some time with your partner. Communicate with your partner as much as possible.

After trying all the above modification in your life style if you cannot find any improvement you can consult your GP and get the suitable medication or treatment for it. Read more on medication used in Erectile dysfunction treatment.

Symptoms of Erectile Dysfunction

Many a times erectile dysfunction occurs only in certain specific situations. Like you may not be able to get an erection when you are with your partner, however you may get an erection when you masturbate or you wake up in morning. In such a cases the cause of erectile dysfunction is mostly psychological. Also if you could not obtain an erection in any circumstances the cause is primarily physical. Read more about psychological and physical erectile dysfunction causes.

If erectile dysfunction persist for more than several weeks, whatever may be the reason physical or psychological; it is recommended to consult your GP. Your GP can easily and correctly diagnose the problem and recommend you the correct treatments. Even if they recommend medication which you are aware about, it is always better to concern your GP first as you should not start any medication unless proved suitable for you. Once recommend by your GP, you can go to genuine online pharmacy and purchase those medication at cheap price.

Some regularly used medications have side effects and they should not be used if few other medicines are being used. You can read about it in side effects section.

Erectile Dysfunction Causes

Erectile Dysfunction Causes

Usually, psychological cause is more likely for erectile dysfunction than a physical cause. There have been cases when normally a man gets erection when he wake up in morning or when he is masturbating, but some time while getting involved in sexual activity, finds difficult to get an erection. In such case it is psychological cause rather than physical. 

Common psychological causes of ED:

• Nervousness
• Guilt
• Depression
• Relationship incompatibility
• Gayness
• Exhaustion

In many cases people are also found with mixture of psychological and physical causes. If the ED is due to a physical cause, you are likely to still have a normal sex drive. 

Common physical causes of ED:

• Smoking
• Excessive drinking
• Diabetes
• Deterioration of the arteries (usually in old age)
• Obesity
• Side effects of certain drugs
• Recreational drugs
  
• Disease of nervous system (rare)
• Hormone problems (rare)
  

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